Multienzyme-mimic nanogels for reactive oxygen species catalyzing and treatment of H2O2-induced vascular endothelium injury in vitro

Oxidative stress relates to acute and chronic inflammatory diseases. However, antioxidant drugs of available clinically are limited. Design a kind of nanoenzyme with excellent catalytic reactive oxygen species (ROS) property and biocompatibility provides a promising way for the treatment of ROS-related inflammation. The active site components and net environment of nanozymes have an important effect on the nanoenzyme activity. Herein, Er3+ doped metal coordinated polymeric nanogels (SiO2@MPG/Er) nanozymes with anti-oxidative activity of are obtained, which treat vascular endothelial cells damage. The greatly dispersed Ce ion in MPGs is a key active center of mimetic enzyme. Meanwhile, Er3+ ions doping increases oxygen vacancies of samples, which further improve enzyme-like catalytic activity. SiO2@MPG/Er nanoenzyme simultaneously possesses glutathione peroxidase (GPX) and catalase (CAT) enzyme activities, which present catalytic ability of ROS and significantly improve treatment effect in vascular endothelium injury. The SiO2@MPG/Er nanozyme pave a new way to treat cardiovascular diseases related to endothelial damage.