Construction of Diverse Heterocycles by Radical NHC Catalysis

Abstract Heterocyclic molecular frameworks are fundamental structural motifs in pharmacologically active compounds and natural products, inspiring ongoing innovation in their synthetic methodologies. This review offers a comprehensive overview of recent advancements in N ‐heterocyclic carbene‐mediated catalytic platforms for heterocycle synthesis, with a particular emphasis on the mechanistic principles driving key transformations. By critically discussing state‐of‐the‐art catalytic systems, we underscore their transformative potential in constructing bioactive heterocyclic scaffolds—such as indole derivatives, furan‐based systems, and phenanthridine frameworks. Moreover, the review highlights efficient and sustainable synthetic strategies that hold significant promise for pharmaceutical development.