Electrochemical Imidoyl Radical‐Involved Functionalization of Isocyanides to Construct Benzotriazole‐Sulfonamide and Guanidine Derivatives

Benzotriazoles and benzenesulfonamides arewidely present in various bioactive molecules, so the development of mild and convenientsynthetic strategies to synthesize compounds containing these functional groups is crucial for discovering candidate therapeutic drugs with higher efficacy and fewer side effects. Herein, we report an imidoyl radical‐involved electrochemical method for the difunctionalization of isocyanides with benzotriazoles and benzenesulfonamides, and also realize the electrochemical reaction of isocyanides with benzotriazoles to construct guanidine derivatives. This strategy achieves the difunctionalization of isocyanide under the action of a base, with benzotriazole as the radical precursor and sulfonamide as the nucleophile. Either does not require a chemical oxidant and can be carried out at room temperature.