基因组
生物
同步
进化生物学
谱系(遗传)
分歧(语言学)
基因组进化
功能分歧
比较基因组学
基因组学
基因组大小
结构变异
遗传学
基因
基因家族
哲学
语言学
作者
Scott Ferguson,Ashley Jones,Kevin Murray,Rose L. Andrew,Benjamin Schwessinger,Justin O. Borevitz
标识
DOI:10.1101/2023.04.19.537464
摘要
Abstract Genomes have a highly organised architecture (non-random organisation of functional and non-functional genetic elements within chromosomes) that is essential for many biological functions, particularly, gene expression and reproduction. Despite the need to conserve genome architecture, a surprisingly high level of structural variation has been observed within species. As species separate and diverge, genome architecture also diverges, becoming increasingly poorly conserved as divergence time increases. However, within plant genomes, the processes of genome architecture divergence are not well described. Here we use long-read sequencing and de novo assembly of 33 phylogenetically diverse, wild and naturally evolving Eucalyptus species, covering 1-50 million years of diverging genome evolution to measure genome architectural conservation and describe architectural divergence. The investigation of these genomes revealed that following lineage divergence genome architecture is highly fragmented by rearrangements. As genomes continue to diverge, the accumulation of mutations and subsequent divergence beyond recognition of rearrangements becomes the primary driver of genome divergence. The loss of syntenic regions also contribute to genome divergence, but at a slower pace than rearrangements. We hypothesise that duplications and translocations are potentially the greatest contributors to Eucalyptus genome divergence.
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