结块
集聚经济
结晶
结块
化学工程
Crystal(编程语言)
材料科学
粘度
位阻效应
粒径
奥斯特瓦尔德成熟
化学
纳米技术
有机化学
复合材料
工程类
计算机科学
程序设计语言
作者
Huixiang Zhang,Shichao Du,Yan Wang,Fumin Xue
出处
期刊:Crystals
[Multidisciplinary Digital Publishing Institute]
日期:2024-07-24
卷期号:14 (8): 676-676
被引量:11
标识
DOI:10.3390/cryst14080676
摘要
Crystal agglomeration is a common phenomenon for most chemicals and pharmaceuticals. The formation of agglomerates usually lowers product purity and generates a broad particle size distribution. This review focuses on preventing agglomeration in solution crystallization, the storage of crystals, and pharmaceutical preparation processes. The agglomeration mechanisms in these stages are analyzed and the effects of operating parameters are summarized. Furthermore, effective control means related to the crystallization environment are elaborated, including solvents, ultrasound, and additives. Special attention is paid to the influence of additives in preventing the aggregation of both suspensions and dried powders. Besides additives used in solution crystallization, the roles of anti-caking agents, stabilizers of nanosuspensions, and excipients of solid dispersions are also discussed. The additive type and properties like hydrophilicity, hydrophobicity, ionic strength, viscosity, the steric hindrance effect, and intermolecular interactions between additives and crystals can greatly affect the degree of agglomeration.
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