Radical addition-triggered remote functionalization of C–H bond via 1, n-hydrogen atom transfer process

The development of a simple and green synthetic strategy for the efficient synthesis of complex biological and pharmaceutical molecules is a continuous quest for organic synthetic chemists. As the element chemically bonds in organic compounds, the selective functionalization of inert C–H bonds has been described as a step and atom-economical method. Given the renaissance in radical chemistry, the activation of C–H bonds involving hydrogen atom transfer (HAT) has led to tremendous growth in this area. Compared with the activation of C–H bond through the HAT process initiated by N-, O-, and C-radicals in situ, the activation of remote C–H bond triggered by the radical addition of multiple bonds is just emerging. Herein, we discuss recent advances in remote C–H functionalization reactions involving the HAT process triggered by radical addition. We outline different examples by considering transformations of the key remote carbon radicals trapped by a catalyst or reagent. This strategy can simultaneously introduce two functional groups into the target molecule and represents one of most attractive strategies for the synthesis of complex molecules.