神经退行性变
阿尔茨海默病
Tau病理学
生物标志物
疾病
神经科学
心理学
医学
τ蛋白
淀粉样蛋白(真菌学)
内科学
病理
化学
生物化学
作者
Umberto Nencha,Isotta Rigoni,Federica Ribaldi,Daniele Altomare,Margitta Seeck,Valentina Garibotto,Serge Vulliémoz,Giovanni B. Frisoni
标识
DOI:10.1016/j.neurobiolaging.2024.03.008
摘要
We assessed the relationship of gamma oscillations with tau deposition in Alzheimer's disease (AD) and other cognitive diseases, as both are altered during the disease course and relate to neurodegeneration. We retrospectively analyzed data from 7 AD, tau positive patients and 9 tau negative patients, who underwent cerebral amyloid PET and tau PET, and EEG within 12 months. Relative gamma power was higher in tau positive (AD) patients than in tau negative patients (p<.05). In tau positive AD patients, tau burden was associated with a linear increase in gamma power (p<.05), while no association was present in the tau negative group nor with amyloid-β burden in either group. Thus, increase in the gamma power might represent a novel biomarker for tau driven neurodegeneration.
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