花椒
杀菌剂
镰刀菌
天然产物
体内
生物
次生代谢物
代谢物
体外
基因
植物
微生物学
生物技术
生物化学
作者
Jiahuan Chen,Yuchen Zhou,Duxuan Liu,Xiaolan Lu,Haoyu Chen,Mengni Huang,Zhiqing Mao,Tao Zhang,Zhen He,Zhong‐Mei Zou,Kun Zhang
标识
DOI:10.1021/acs.jafc.3c09513
摘要
Pathogenic fungi pose a significant threat to crop yields and human healthy, and the subsequent fungicide resistance has greatly aggravated these agricultural and medical challenges. Hence, the development of new fungicides with higher efficiency and greater environmental friendliness is urgently required. In this study, luvangetin, isolated and identified from the root of Zanthoxylum avicennae, exhibited wide-spectrum antifungal activity in vivo and in vitro. Integrated omics and in vitro and in vivo transcriptional analyses revealed that luvangetin inhibited GAL4-like Zn(II)2Cys6 transcriptional factor-mediated transcription, particularly the FvFUM21-mediated FUM cluster gene expression, and decreased the biosynthesis of fumonisins inFusarium verticillioides. Moreover, luvangetin binds to the double-stranded DNA helix in vitro in the groove mode. We isolated and identified luvangetin, a natural metabolite from a traditional Chinese edible medicinal plant and uncovered its multipathogen resistance mechanism. This study is the first to reveal the mechanism underlying the antifungal activity of luvangetin and provides a promising direction for the future use of plant-derived natural products to prevent and control plant and animal pathogenic fungi.
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