化学
四糖
空肠弯曲杆菌
另一个
全合成
立体化学
分子内力
部分
连接器
微生物学
多糖
生物化学
细菌
生物
计算机科学
遗传学
操作系统
作者
Chun‐Hong Yeh,Ya-Jou Chang,Tsung-Juin Lin,Cheng‐Chung Wang
摘要
The infection of Campylobacter jejuni results in a significant diarrhea disease, which is highly fatal to young children in unindustrialized countries. Developing a new therapy is required due to increasing antibiotic resistance. Herein, we described a total synthesis of a C. jejuni NCTC11168 capsular polysaccharide repeating unit containing a linker moiety via an intramolecular anomeric protection (iMAP) strategy. This one-step 1,6-protecting method structured the challenging furanosyl galactosamine configuration, facilitated further concise regioselective protection, and smoothed the heptose synthesis. The tetrasaccharide was constructed in a [2 + 1 + 1] manner. The synthesis of this complicated CPS tetrasaccharide was completed in merely 28 steps, including the preparation of all the building blocks, construction of the tetrasaccharide skeleton, and functional group transformations.
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