Surface-Functionalized NdVO4:Gd3+ Nanoplates as Active Agents for Near-Infrared-Light-Triggered and Multimodal-Imaging-Guided Photothermal Therapy

光热治疗 生物相容性 吸收(声学) 材料科学 纳米技术 纳米材料 磁共振成像 体内 化学 生物医学工程 医学 复合材料 冶金 生物技术 放射科 生物
作者
Kerong Deng,Donglian Liu,Ziyan Wang,Zhaoru Zhou,Qianyi Chen,Jiamin Luo,Yaru Zhang,Zhiyao Hou,Jun Lin
出处
期刊:Pharmaceutics [Multidisciplinary Digital Publishing Institute]
卷期号:14 (6): 1217-1217 被引量:10
标识
DOI:10.3390/pharmaceutics14061217
摘要

Development of nanotheranostic agents with near-infrared (NIR) absorption offers an effective tool for fighting malignant diseases. Lanthanide ion neodymium (Nd3+)-based nanomaterials, due to the maximum absorption at around 800 nm and unique optical properties, have caught great attention as potential agents for simultaneous cancer diagnosis and therapy. Herein, we employed an active nanoplatform based on gadolinium-ion-doped NdVO4 nanoplates (NdVO4:Gd3+ NPs) for multiple-imaging-assisted photothermal therapy. These NPs exhibited enhanced NIR absorption and excellent biocompatibility after being grafted with polydopamine (pDA) and bovine serum albumin (BSA) layers on their surface. Upon expose to an 808 nm laser, these resulting NPs were able to trigger hyperthermia rapidly and cause photo-destruction of cancer cells. In a xenograft tumor model, tumor growth was also significantly inhibited by these photothermal agents under NIR laser irradiation. Owing to the multicomponent nanostructures, we demonstrated these nanoagents as being novel contrast agents for in vivo magnetic resonance (MR) imaging, X-ray computed tomography (CT), photoacoustic (PA) imaging, and second biological window fluorescent imaging of tumor models. Thus, we believe that this new kind of nanotherapeutic will benefit the development of emerging nanosystems for biological imaging and cancer therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丶whist完成签到,获得积分10
刚刚
科研通AI5应助Zekun采纳,获得10
1秒前
maoyuni发布了新的文献求助10
1秒前
搜集达人应助茂茂采纳,获得10
3秒前
3秒前
4秒前
深藏blue发布了新的文献求助10
4秒前
田様应助wenlin采纳,获得10
4秒前
可爱的函函应助雪山飞龙采纳,获得10
5秒前
5秒前
杭谷波完成签到,获得积分10
5秒前
李子敬完成签到,获得积分10
6秒前
陈小纯完成签到,获得积分20
7秒前
8秒前
yyx发布了新的文献求助10
9秒前
9秒前
画龙完成签到,获得积分10
10秒前
田様应助云上人采纳,获得10
12秒前
clairevox完成签到,获得积分10
15秒前
科研通AI5应助Adzuki0812采纳,获得10
16秒前
17秒前
17秒前
深情安青应助深藏blue采纳,获得10
18秒前
大模型应助闲得追月时采纳,获得30
19秒前
19秒前
19秒前
Willing发布了新的文献求助10
19秒前
香蕉觅云应助孤独灰狼采纳,获得10
19秒前
20秒前
21秒前
胡先生发布了新的文献求助30
22秒前
云上人发布了新的文献求助10
23秒前
sissi完成签到,获得积分10
23秒前
12138的9527完成签到,获得积分10
23秒前
认真雅阳发布了新的文献求助10
24秒前
24秒前
wenlin发布了新的文献求助10
24秒前
24秒前
离言发布了新的文献求助30
26秒前
自信鑫鹏完成签到,获得积分10
28秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Mobilization, center-periphery structures and nation-building 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
Technologies supporting mass customization of apparel: A pilot project 450
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 430
Multichannel rotary joints-How they work 400
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3795227
求助须知:如何正确求助?哪些是违规求助? 3340218
关于积分的说明 10299325
捐赠科研通 3056829
什么是DOI,文献DOI怎么找? 1677185
邀请新用户注册赠送积分活动 805274
科研通“疑难数据库(出版商)”最低求助积分说明 762420