化学
苯胺
烷基化
镍
催化作用
光催化
组合化学
烷基
迁移插入
有机化学
光催化
作者
Xian Zhao,Xinglei Feng,Fan Chen,Shuaishuai Zhu,Feng‐Ling Qing,Lingling Chu
标识
DOI:10.1002/ange.202111061
摘要
Abstract A metallaphotoredox‐catalyzed strategy for the selective and divergent aminocarbonylation of alkynes with amines and 1 atm of CO is reported. This synergistic protocol not only enables the Markovnikov‐selective hydroaminocarbonylation of alkynes to afford α,β‐unsaturated amides, but also facilitates a sequential four‐component hydroaminocarbonylation/radical alkylation in the presence of tertiary and secondary alkyl boronate esters, which allows for straightforward conversion of alkynes into corresponding amides. Preliminary mechanistic studies disclose that a photoinduced oxidative insertion of aniline and CO into nickel followed by a migratory insertion of (carbamoyl)nickel species could be involved.
科研通智能强力驱动
Strongly Powered by AbleSci AI