化学
精氨酸
卡纳瓦尼
肽
辛醇
磷酸盐
细胞
硫酸盐
生物化学
氨基酸
立体化学
色谱法
有机化学
分配系数
作者
Lindsey O. Calabretta,Vienna M. Thomas,Ronald T. Raines
标识
DOI:10.1016/j.tetlet.2022.153848
摘要
Octanol-water partitioning experiments in the presence of carboxylate-, phosphate-, and sulfate-containing anionic lipids revealed that Ac-Cav-NH2 (where Cav refers to δ-oxa-arginine) partitions less into octanol than does Ac-Arg-NH2, suggesting that a cell-penetrating peptide based on canavanine would be relatively ineffective.
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