丙二酸
化学
亲核细胞
试剂
取代基
有机化学
组合化学
催化作用
作者
Tania Xavier,Sylvie Condon,Christophe Pichon,Erwan Le Gall,Marc Presset
标识
DOI:10.1002/ejoc.202101392
摘要
Abstract Substituted malonic acid half‐oxyesters (SMAHOs) constitute an original family of malonic acid derivatives. They could be mostly used as pro‐nucleophiles through decarboxylative processes, making them enolate equivalents for the elaboration of greener methodologies. In addition to the native ester function, the presence of a substituent on the malonic position affords additional opportunities for structural diversification. These reagents are particularly well‐suited for the development of organocatalyzed processes, which has recently led to olefination and addition reactions as relevant synthetic routes to elaborated structures under mild conditions.
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