竞争对手
多奈哌齐
加兰他明
医学
石杉碱甲
科克伦图书馆
不利影响
脑活素
日常生活活动
疾病
认知
银杏
痴呆
药理学
重症监护医学
内科学
荟萃分析
精神科
乙酰胆碱酯酶
化学
酶
生物化学
作者
Fangcheng Fan,Liu Hua,Shi Xiao,Yangwen Ai,Qingshan Liu,Yong Cheng
摘要
Evidence summaries for efficacy and safety of frequently employed treatments of Alzheimer's disease (AD) are sparse.We aimed to perform an updated umbrella review to identify an efficacious and safe treatment for AD patients.We conducted a search for meta-analyses and systematic reviews on the Embase, PubMed, The Cochrane Library, and Web of Science to address this knowledge gap. We examined the cognitive functions, behavioral symptoms, global clinical assessment, and Activities of Daily Living as efficacy endpoints, and the incidence of adverse events as safety profiles.Sixteen eligible papers including 149 studies were included in the umbrella review. The results showed that AChE inhibitors (donepezil, galantamine, rivastigmine, Huperzine A), Ginkgo biloba, and cerebrolysin appear to be beneficial for cognitive, global performances, and activities of daily living in patients with AD. Furthermore, anti-Aβ agents are unlikely to have an important effect on slowing cognitive or functional impairment in mild to moderate AD.Our study demonstrated that AChE inhibitors, Ginkgo biloba, and cerebrolysin are the optimum cognitive and activities of daily living medication for patients with AD.
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