氨基酰化
终端(电信)
催化作用
组分(热力学)
化学
组合化学
计算机科学
有机化学
物理
转移RNA
生物化学
电信
核糖核酸
热力学
基因
作者
Shuo Tong,Cyril Piemontesi,Qian Wang,Mei‐Xiang Wang,Jieping Zhu
标识
DOI:10.1002/anie.201704727
摘要
The reaction of secondary homopropargylamines, isocyanides, and water in the presence of a catalytic amount of silver acetate and subsequent purification by chromatography on silica gel afforded substituted proline amides in good to excellent yields. Primary homopropargylamines underwent a cyclizative Ugi-Joullié three-component reaction with isocyanides and carboxylic acids to afford functionalized N-acyl proline amides. High diastereoselectivity was observed in the synthesis of 4-alkoxy and 4,5-disubstituted proline derivatives. This work represents the first examples of a three-component cyclizative 1,1-aminoacylation of terminal alkynes.
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