钌
材料科学
光动力疗法
光化学
荧光
金属有机骨架
生物相容性
纳米颗粒
荧光寿命成像显微镜
量子产额
双光子激发显微术
发光
纳米技术
化学
催化作用
光电子学
物理化学
有机化学
光学
吸附
冶金
物理
作者
Rui Chen,Jinfeng Zhang,Jipsa Chelora,Yuan Xiong,Stephen V. Kershaw,King Fai Li,Pik Kwan Lo,Kok Wai Cheah,Andrey L. Rogach,Juan Antonio Zapien,Chun‐Sing Lee
标识
DOI:10.1021/acsami.6b12469
摘要
Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)32+) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)32+ guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)32+-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)32+-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)32+-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.
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