血红素加氧酶
小胶质细胞
神经炎症
化学
神经保护
SH-SY5Y型
一氧化氮合酶
p38丝裂原活化蛋白激酶
肿瘤坏死因子α
蛋白激酶B
氧化应激
一氧化氮
活力测定
细胞生物学
药理学
生物化学
血红素
蛋白激酶A
信号转导
磷酸化
炎症
细胞
免疫学
生物
细胞培养
酶
神经母细胞瘤
有机化学
遗传学
作者
Mina K. Kim,Sang Yoon Choi,Kyung-Tak Kim,Young Kyoung Rhee,Jinyoung Hur
标识
DOI:10.1016/j.jff.2017.01.025
摘要
Neurodegenerative disease states are typified by the presence of activated microglia and maladaptive neuron-microglia interactions. Thus, there is a need for agents that target pathological cell-cell interactions. We tested the hypothesis that ginsenoside Rg18 (NGA), a constituent of Panax ginseng root, in part mediates the beneficial effects of Panax ginseng. In lipopolysaccharide-stimulated BV2 microglia, NGA decreased the expression of cyclooxygenase-2, tumour necrosis factor-α, IL-1β and inducible nitric oxide synthase as well as NO synthesis. NGA also inhibited p38 mitogen-activated protein kinase and STAT1 phosphorylation. In SH-SY5Y neurons subjected to amyloid-beta (Aβ) oligomer cytotoxicity, NGA promoted cell viability and up-regulated nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) in a manner associated with Akt/ERK1/2 activation. Taken together, these results suggest that NGA is a functional food constituent that exerts neuroprotective effects.
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