比较基因组杂交
杂合子丢失
生物
单亲二体
拷贝数变化
遗传学
基因组
荧光原位杂交
计算生物学
微阵列
DNA微阵列
基因
染色体
核型
基因表达
等位基因
作者
Chengsheng Zhang,Eliza Cerveira,Mallory Romanovitch,Qihui Zhu
出处
期刊:Methods in molecular biology
日期:2016-12-02
卷期号:: 167-179
被引量:7
标识
DOI:10.1007/978-1-4939-6703-2_15
摘要
Copy number variations (CNVs) in the genomes have been suggested to play important roles in human evolution, genetic diversity, and disease susceptibility. A number of assays have been developed for the detection of CNVs, including fluorescent in situ hybridization (FISH), array-based comparative genomic hybridization (aCGH), PCR-based assays, and next-generation sequencing (NGS). In this chapter, we describe a microarray method that has been used for the detection of genome-wide CNVs, loss of heterozygosity (LOH), and uniparental disomy (UPD) associated with constitutional and neoplastic disorders.
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