CD44细胞
细胞生物学
促炎细胞因子
细胞粘附分子
细胞粘附
细胞外基质
免疫系统
肿瘤坏死因子α
化学
硫酸化
细胞因子
内皮
生物
免疫学
炎症
细胞
生物化学
内分泌学
作者
Arpita Maiti,Guitta Maki,Pauline Johnson
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1998-10-30
卷期号:282 (5390): 941-943
被引量:139
标识
DOI:10.1126/science.282.5390.941
摘要
Regulation of cell adhesion is important for immune system function. CD44 is a tightly regulated cell adhesion molecule present on leukocytes and implicated in their attachment to endothelium during an inflammatory immune response. The proinflammatory cytokine tumor necrosis factor–α, but not interferon-γ, was found to convert CD44 from its inactive, nonbinding form to its active form by inducing the sulfation of CD44. This posttranslational modification was required for CD44-mediated binding to the extracellular matrix component hyaluronan and to vascular endothelial cells. Sulfation is thus a potential means of regulating CD44-mediated leukocyte adhesion at inflammatory sites.
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