组织因子
淋巴瘤
医学
病理
纤维蛋白原
弥漫性血管内凝血
血管性血友病因子
血栓调节蛋白
凝结
T细胞淋巴瘤
免疫学
内科学
血小板
凝血酶
作者
Tomohiro Sase,Hideo Wada,Motoko Yamaguchi,Sachiko Ogawa,Yuko Kamikura,Masakatsu Nishikawa,Toshihiro Kaneko,Yasunori Abe,Junji Nishioka,Tsutomu Nobori,Hiroshi Shiku
出处
期刊:Thrombosis and Haemostasis
[Georg Thieme Verlag KG]
日期:2005-01-01
卷期号:93 (01): 153-159
被引量:30
摘要
We examined haemostatic abnormalities and thrombotic disorders in 217 patients with malignant lymphoma. Plasma levels of fibrinogen and D-dimer were significantly higher in patients with malignant lymphoma than in healthy subjects. The incidence of severe complications, such as disseminated intravascular coagulation (DIC) and interstitial pneumonia (IP), differed with each clinical stage or histological type, but they occurred frequently in stage IV or natural killer (NK) cell lymphoma. Plasma levels of fibrinogen degradation products (FDP) and D-dimer, leukocyte tissue factor (TF) mRNA and plasma TF antigen were significantly higher in stage IV than in stage I, II or III. Plasma levels of FDP, D-dimer, and leukocyte TF mRNA in NK cell lymphoma were markedly higher than in other types of lymphoma. Immunohistochemical staining of NK cell lymphoma revealed that granulocyte macrophage colony-stimulating factor was positive in tumour cells, whereas von Willebrand factor and TF were positive in vascular endothelial cells of surrounding tissue. Our results suggested that patients with stage IV disease and NK cell lymphoma were in abnormal thrombotic and haemostatic state, and may frequently develop DIC and IP. One of the mechanisms of DIC and IP may involve elevated cytokine production by lymphoma cells, which can stimulate the expression of TF in blood cells or surrounding tissue.
科研通智能强力驱动
Strongly Powered by AbleSci AI