5-羟色胺能
神经科学
血清素
谷氨酸的
神经递质
胆碱能的
多巴胺能
5-羟色胺受体
多巴胺
神经传递
乙酰胆碱
谷氨酸受体
化学
心理学
受体
生物
中枢神经系统
内分泌学
生物化学
作者
Mohammad Seyedabadi,Gohar Fakhfouri,Vahid Ramezani,Shahram Ejtemaei Mehr,Reza Rahimian
标识
DOI:10.1007/s00221-013-3818-4
摘要
Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many physiological or pathophysiological processes including cognitive function. Seven distinct receptors (5-HT1-7), each with several subpopulations, have been identified for serotonin, which are different in terms of localization and downstream signaling. Because of the development of selective agonists and antagonists for these receptors as well as transgenic animal models of cognitive disorders, our understanding of the role of serotonergic transmission in learning and memory has improved in recent years. A large body of evidence indicates the interplay between serotonergic transmission and other neurotransmitters including acetylcholine, dopamine, γ-aminobutyric acid (GABA) and glutamate, in the neurobiological control of learning and memory. In addition, there has been an alteration in the density of serotonergic receptors in aging and Alzheimer's disease, and serotonin modulators are found to alter the process of amyloidogenesis and exert cognitive-enhancing properties. Here, we discuss the serotonin-induced modulation of various systems involved in mnesic function including cholinergic, dopaminergic, GABAergic, glutamatergic transmissions as well as amyloidogenesis and intracellular pathways.
科研通智能强力驱动
Strongly Powered by AbleSci AI