瘦素
内科学
内分泌学
脂肪组织
脂解
胰岛素
脂联素
脂肪细胞
脂质代谢
激素
白色脂肪组织
生物
糖皮质激素
脂蛋白脂酶
脂肪因子
化学
胰岛素抵抗
医学
肥胖
作者
María Elena Trujillo Ortega,Sean Sullivan,Ingrid A. Harten,Stephen H. Schneider,Andrew S. Greenberg,Susan K. Fried
摘要
Adipose tissue IL-6 expression is increased in obesity and is a strong predictor of abnormalities in adipocyte and systemic metabolism. We used adipose tissue organ culture to test the direct effects of IL-6 on leptin expression, lipolysis, and lipoprotein lipase activity. To assess possible interactions with the hormonal milieu, IL-6 effects were tested in the presence or absence of insulin and/or glucocorticoid [dexamethasone (dex)]. Because omental (Om) and abdominal sc depots differ in IL-6 expression, their responses to exogenous IL-6 were compared. Although IL-6 had no significant effects under basal conditions, culture with the combination of IL-6 and dex, compared with dex alone, for 2 d increased leptin in both depots [+95 ± 30% (sc) and +67 ± 19% (Om), P < 0.01]; IL-6 did not affect leptin production when added in the presence of insulin. Culture with IL-6 in the absence of hormones moderately increased lipolysis during culture in both sc and Om [+79 ± 23% (sc) and +26 ± 9% (Om), each P < 0.01]. IL-6 markedly reduced the high levels of lipoprotein lipase activity in tissue cultured with insulin plus dex. We conclude that high local concentrations of IL-6 can modulate leptin production and lipid metabolism in human adipose tissue.
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