Upregulation of Endothelial and Inducible Nitric Oxide Synthase Expression by Reactive Oxygen Species

An increase in ROS activity upregulates NOS expression in vitro in HCAECs grown in culture, and also in vivo in animals. This effect appears to be, in part, mediated by limiting the availability of NO, thereby exerting a negative feedback influence on NOS expression through activation of NFkappaB.