神经营养素
trk受体
神经科学
生物
原肌球蛋白受体激酶A
低亲和力神经生长因子受体
细胞生物学
原肌球蛋白受体激酶B
受体
原肌球蛋白受体激酶C
突触可塑性
神经营养因子
血小板源性生长因子受体
生物化学
生长因子
作者
Bai Lu,Petti T. Pang,Newton H. Woo
摘要
Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors (proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal survival and enhance synaptic plasticity by activating Trk receptor tyrosine kinases. Recent studies indicate that proneurotrophins serve as signalling molecules by interacting with the p75 neurotrophin receptor (p75NTR). Interestingly, proneurotrophins often have biological effects that oppose those of mature neurotrophins. Therefore, the proteolytic cleavage of proneurotrophins represents a mechanism that controls the direction of action of neurotrophins. New insights into the 'yin and yang' of neurotrophin activity have profound implications for our understanding of the role of neurotrophins in a wide range of cellular processes.
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