化学
细胞毒性
质谱法
五味子
二维核磁共振波谱
立体化学
生物化学
色谱法
体外
医学
替代医学
中医药
病理
作者
Wei‐Lie Xiao,Yingli Wu,Shan‐Zhai Shang,Fei He,Xiao Luo,Guangyu Yang,Jian‐Xin Pu,Guoqiang Chen,Han‐Dong Sun
标识
DOI:10.1002/hlca.201000004
摘要
Abstract Four new highly oxygenated nortriterpenoids, lancifodilactones O–R ( 1 – 4 ), together with six known ones, i.e. , 5 – 10 , were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments and mass spectrometry. Compounds 1 – 3 were evaluated for their cytotoxicity against NB4, A549, SHSY5Y, PC‐3, and MCF‐7 cell lines. No compounds exhibited significant cytotoxicity, the IC 50 values being above 50 μ M .
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