爪蟾
双稳态
细胞命运测定
细胞周期蛋白依赖激酶1
卵母细胞
蛋白激酶A
细胞生物学
刺激(心理学)
MAPK/ERK通路
生物
激酶
非正面反馈
正面反馈
细胞
细胞周期
转录因子
物理
生物化学
心理学
胚胎
电压
工程类
电气工程
基因
心理治疗师
量子力学
作者
Wen Cheng Xiong,James E. Ferrell
出处
期刊:Nature
[Springer Nature]
日期:2003-11-27
卷期号:426 (6965): 460-465
被引量:702
摘要
The maturation of Xenopus oocytes can be thought of as a process of cell fate induction, with the immature oocyte representing the default fate and the mature oocyte representing the induced fate1,2. Crucial mediators of Xenopus oocyte maturation, including the p42 mitogen-activated protein kinase (MAPK) and the cell-division cycle protein kinase Cdc2, are known to be organized into positive feedback loops3. In principle, such positive feedback loops could produce an actively maintained ‘memory’ of a transient inductive stimulus and could explain the irreversibility of maturation3,4,5,6. Here we show that the p42 MAPK and Cdc2 system normally generates an irreversible biochemical response from a transient stimulus, but the response becomes transient when positive feedback is blocked. Our results explain how a group of intrinsically reversible signal transducers can generate an irreversible response at a systems level, and show how a cell fate can be maintained by a self-sustaining pattern of protein kinase activation.
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