鼻病毒
化学
亲脂性
衣壳
极性(国际关系)
生物物理学
病毒
立体化学
生物化学
病毒学
细胞
基因
生物
作者
Andrew Morley,Nicholas P. Tomkinson,Andrew Cook,Catherine Macdonald,Richard Weaver,Sarah King,Lesley Jenkinson,John Unitt,Christopher McCrae,Tim Phillips
标识
DOI:10.1016/j.bmcl.2011.08.083
摘要
To try and generate broad spectrum human rhinovirus VP1 inhibitors with more attractive physicochemical, DMPK and safety profiles, we explored the current SAR of known VP1 compounds. This lead to the identification of specific structural regions where reduction in polarity can be achieved, so guiding chemistry to analogues with significantly superior profiles to previously reported inhibitors.
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