Atrial resynchronization therapy: An emerging potential to advance physiologic pacing?

Sick sinus syndrome (SSS) represents the most common indication for permanent pacemaker implantation.1 SSS is characterized by atrial arrhythmias and sinus node dysfunction manifesting as sinus pauses, bradycardia, and chronotropic incompetence. 1 The prevalence of atrial fibrillation (AF), the most common atrial arrhythmia in patients with SSS, increases exponentially with age.1 Both sinus node dysfunction and atrial arrhythmias result from age-related structural and electrophysiological changes.