视黄醇X受体
部分
维甲酸
化学
苯并噻唑
立体化学
青霉属
转录活性
生物化学
核受体
转录因子
维甲酸
基因
食品科学
作者
Conghua Xie,Duo Zhang,Kaiqiang Guo,Qing‐Xiang Yan,Zheng‐Biao Zou,Zhijun He,Zhen Wu,Xiaokun Zhang,Haifeng Chen,Xian‐Wen Yang
标识
DOI:10.1016/j.cclet.2021.09.073
摘要
A novel meroterpenoid, named meroterpenthiazole A (1), was isolated from the deep-sea-derived Penicillium allii-sativi. Its structure was established by extensive spectroscopic and computational methods. Meroterpenthiazole A bears a rare benzothiazole moiety in nature. Compound 1 significantly inhibited retinoid X receptor (RXR)-α transcriptional effect (KD = 12.3 µmol/L) through a novel binding mechanism.
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