肠道菌群
生物
黄腐酚
生物利用度
脂质代谢
卡路里
肥胖
微生物群
内分泌学
食品科学
作者
Isabelle E. Logan,Natalia Shulzhenko,Thomas J. Sharpton,Gerd Bobe,Kitty Liu,Stephanie Nuss,Megan L. Jones,Cristobal L. Miranda,Stephany Vasquez-Perez,Jamie M. Pennington,Scott W. Leonard,Jaewoo Choi,Wenbin Wu,Manoj Gurung,Joyce P. Kim,Malcolm B. Lowry,Andrey Morgun,Claudia S. Maier,Jan F. Stevens,Adrian F. Gombart
标识
DOI:10.1002/mnfr.202100389
摘要
Scope The polyphenol xanthohumol (XN) improves dysfunctional glucose and lipid metabolism in diet-induced obesity animal models. Because XN changes intestinal microbiota composition, the study hypothesizes that XN requires the microbiota to mediate its benefits. Methods and Results To test the hypothesis, the study feeds conventional and germ-free male Swiss Webster mice either a low-fat diet (LFD, 10% fat derived calories), a high-fat diet (HFD, 60% fat derived calories), or a high-fat diet supplemented with XN at 60 mg kg−1 body weight per day (HXN) for 10 weeks, and measure parameters of glucose and lipid metabolism. In conventional mice, the study discovers XN supplementation decreases plasma insulin concentrations and improves Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). In germ-free mice, XN supplementation fails to improve these outcomes. Fecal sample 16S rRNA gene sequencing analysis suggests XN supplementation changes microbial composition and dramatically alters the predicted functional capacity of the intestinal microbiota. Furthermore, the intestinal microbiota metabolizes XN into bioactive compounds, including dihydroxanthohumol (DXN), an anti-obesogenic compound with improved bioavailability. Conclusion XN requires the intestinal microbiota to mediate its benefits, which involves complex diet-host-microbiota interactions with changes in both microbial composition and functional capacity. The study results warrant future metagenomic studies which will provide insight into complex microbe-microbe interactions and diet-host-microbiota interactions.
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