化学
对接(动物)
组合化学
计算化学
有机化学
立体化学
作者
S. Durga Karteek,A. Gopi Reddy,M. Bhuvan Tej,M. V. Basaveswara Rao
出处
期刊:Russian Journal of Organic Chemistry
[Springer Nature]
日期:2021-02-01
卷期号:57 (2): 272-282
标识
DOI:10.1134/s1070428021020196
摘要
A new series of fused tricyclic coumarin derivatives were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by molecular docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compounds.
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