医学
化疗
肿瘤科
内科学
肺癌
癌症研究
生物信息学
抗性(生态学)
生物
生态学
作者
Brett H. Herzog,Siddhartha Devarakonda,Ramaswamy Govindan
标识
DOI:10.1016/j.jtho.2021.07.018
摘要
SCLC is an aggressive form of lung cancer with a very poor prognosis. Although SCLC initially responds very well to platinum-based chemotherapy, it eventually recurs and at recurrence is nearly universally resistant to therapy. In light of the recent advances in understanding regarding the biology of SCLC, we review findings related to SCLC chemotherapy resistance. We discuss the potential clinical implications of recent preclinical discoveries in altered signaling pathways, transcriptional landscapes, metabolic vulnerabilities, and the tumor microenvironment.
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