T细胞受体
生物
白细胞介素2受体
细胞生物学
主要组织相容性复合体
T细胞
免疫耐受
受体
免疫系统
信号转导
FOXP3型
效应器
调节性T细胞
免疫学
转录因子
作者
Naganari Ohkura,Shimon Sakaguchi
标识
DOI:10.1007/s00281-010-0200-5
摘要
Naturally arising CD4+CD25+ regulatory T cells (Treg cells), which specifically express the forkhead family transcription factor Foxp3, are essential for the maintenance of immunological self-tolerance and immune homeostasis. Stimulation of the T cell antigen receptor (TCR) via recognizing self-peptide/major histocompatibility complex (MHC) is required for their expression of Foxp3 in the course of their development in the thymus. The TCR repertoires displayed by Treg cells and naïve T cells are apparently distinct, suggesting that Treg cells with high reactivity to self-peptide/MHC ligands are somehow driven to Treg cell lineage in the thymus. Treg cells also require stimulation via TCR to exert suppression in the periphery. At the molecular level, assembly of Foxp3, Foxp3-interacting factors, and chromatin-remodeling factors is in part under the control of TCR signaling, and TCR stimulation alters Foxp3-dependent transcriptional regulation, protein–protein interaction, and Foxp3 recruitment to the specific genomic loci. These findings collectively indicate that the TCR signaling is essential for suppressive function of Treg cells and that TCR has a determinant role for driving developing T cells to the Foxp3+CD4+CD25+ Treg cell lineage and differentiation.
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