Process Improvement on the Synthesis of Telavancin-Derivative of Vancomycin

This article was the process improvement of telavancin synthesis.The key intermediate N-Fmoc-decyl-aminoacetaldehyde was obtained through continuous reaction method, followed by one-pot condensation and Mannich reaction.Telavancin hydrochloride was finnally obtained via reversed phase silica gel.The HPLC purity and total yield of this route were higher than the existing literatures.It was easy to operate, environmentally friendly, lower costs, and suitable for industrialized production.