纳米载体
癌症干细胞
乳腺癌
Abcg2型
阿霉素
药理学
多重耐药
药物输送
癌症研究
介孔二氧化硅
抗药性
癌症
医学
化学
药品
化疗
材料科学
纳米技术
生物
ATP结合盒运输机
内科学
介孔材料
运输机
生物化学
催化作用
基因
微生物学
作者
Yuanwei Pan,Shihong Zhou,Yan Li,Badri Parshad,Wenzhong Li,Rainer Haag
标识
DOI:10.1016/j.jconrel.2020.11.015
摘要
Multidrug resistance (MDR) of cancer stem cells (CSCs) is a major hurdle to chemotherapy, and it is very important to develop CSCs-specific targeted nanocarriers for the treatment of drug resistant CSCs. In this work, we developed CSCs-specific targeted mSiO2-dPG nanocarriers simultaneous delivery chemotherapy drug DOX along with the P-glycoprotein (P-gp) inhibitor tariquidar (Tar) for enhanced chemotherapy to overcome MDR in breast CSCs. The mSiO2-dPG nanocarriers possess a high loading capability, excellent pH stimuli-responsive performance, and good biocompatibility. With the help of CSCs-specific targeting and P-gp inhibitor Tar, the accumulation of DOX delivered by the mSiO2-dPG nanocarriers could be greatly increased in drug resistant three-dimensional mammosphere of breast CSCs, and the chemotherapeutic efficacy against breast CSCs was enhanced. Moreover, the expression of stemness-associated gene and tumorspheres' formation ability was also significantly suppressed, which indicates the excellent capability for overcoming MDR of breast CSCs. Taken together, we developed a CSCs-specific targeted mSiO2-dPG nanocarriers for co-delivery DOX and Tar, which provide a promising approach to effectively eliminate the CSCs and overcome the MDR of breast CSCs.
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