Immunization of Cats to Induce Neutralizing Antibodies Against Fel D 1, the Major Feline Allergen in Human Subjects

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AAP Policy SupplementsSupplements Publish Supplement MultimediaVideo Abstracts Pediatrics On Call Podcast Subscribe Alerts Careers We will not be accepting article comments until November 8, 2021, while our site undergoes major changes. We apologize for the inconvenience. For questions, contact the editorial office. Allergy Immunization of Cats to Induce Neutralizing Antibodies Against Fel D 1, the Major Feline Allergen in Human Subjects John M. Kelso Pediatrics December 2020, 146 (Supplement 4) S337; DOI: https://doi.org/10.1542/peds.2020-023861AA John M. Kelso San Diego, CaliforniaFind this author on Google ScholarFind this author on PubMedSearch for this author on this site ArticleInfo & MetricsComments Download PDF F Thoms, GT Jennings, M Maudrich. J Allergy Clin Immunol. 2019;144(1):193–203PURPOSE OF THE STUDY:Cats are found in 25% of US households, and 10% of humans are allergic to them. Most cat-allergic subjects make IgE antibody to the major cat allergen Fel d 1. If environmental control measures and medication fail to provide sufficient control of allergic symptoms, allergen immunotherapy can be beneficial. What about immunizing the cat instead?STUDY POPULATION:Domestic cats.METHODS:The cats received a series of 3 intramuscular injections at 3-week intervals of a conjugate vaccine consisting of recombinant Fel d 1 and a virus-like particle (VLP) carrier (Fel-CuMVTT). The VLP does not contain viral genetic material but does represent a pathogen-associated structural pattern and also carries RNA from the bacterial production strain, which is a ligand for Toll-like receptors 7 and 8 and is a pathogen-associated molecular pattern, thus providing an immunostimulatory vehicle. Anti–Fel d 1 IgG was measured in the cats after immunization, as was the amount of Fel d 1 in the cats’ tears.RESULTS:Before immunization, there was no detectable anti–Fel d 1. Fel d 1–specific IgG was detected on day 22 after a single immunization, increased further after the second immunization, and was maintained after the third immunization for 282 days (last blood sample collection). There was a significant mean reduction of Fel d 1 in cat tears by a factor of 2.7 that was maintained up to 84 days (last tear sample collection). No signs of toxicity were seen in the cats.CONCLUSIONS:Cat vaccination with Fel-CuMVTT induces neutralizing antibodies, and this could be a novel method to address allergic symptoms in cat owners.REVIEWER COMMENTS:This is a very ingenious approach to cat allergy. Rather than injecting cat-allergic humans with Fel d 1 to make IgG, we may be able to inject the cat with Fel d 1 to make IgG, resulting in less Fel d 1 expression by the cat and fewer symptoms in the owner. Future studies will need to determine whether this approach decreases Fel d 1 production in sebaceous glands and dander and ultimately airborne levels, and whether this leads to sufficient reduction of human symptoms. Presumably, because the cats themselves are not allergic to Fel d 1, they do not need to sit in the waiting room for 30 minutes after each injection.Copyright © 2020 by the American Academy of Pediatrics PreviousNext Back to top Advertising Disclaimer » In this issue Pediatrics Vol. 146, Issue Supplement 4 1 Dec 2020 Table of ContentsIndex by author View this article with LENS PreviousNext Email Article Thank you for your interest in spreading the word on American Academy of Pediatrics.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. 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Kelso Pediatrics Dec 2020, 146 (Supplement 4) S337; DOI: 10.1542/peds.2020-023861AA Citation Manager Formats BibTeXBookendsEasyBibEndNote (tagged)EndNote 8 (xml)MedlarsMendeleyPapersRefWorks TaggedRef ManagerRISZotero Share Immunization of Cats to Induce Neutralizing Antibodies Against Fel D 1, the Major Feline Allergen in Human Subjects John M. Kelso Pediatrics Dec 2020, 146 (Supplement 4) S337; DOI: 10.1542/peds.2020-023861AA Share This Article: Copy Print Download PDF Insight Alerts Table of Contents Jump to section ArticlePURPOSE OF THE STUDY:STUDY POPULATION:METHODS:RESULTS:CONCLUSIONS:REVIEWER COMMENTS:Info & MetricsComments Related ArticlesNo related articles found.Google Scholar Cited By...No citing articles found.Google Scholar More in this TOC SectionAllergy Dog Ownership at 3 Months of Age is Associated With Protection Against Food Allergy Staphylococcus aureus Antibiotic Susceptibility Patterns in Pediatric Atopic Dermatitis Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood Show more Allergy Allergic Rhinitis Perceived Versus Actual Aeroallergen Sensitization in Urban Children Molecular Allergy Diagnostics Refine Characterization of Children Sensitized to Dog Dander Show more Allergic Rhinitis Similar Articles Journal Info Editorial Board Editorial Policies Overview Licensing Information Authors/Reviewers Author Guidelines Submit My Manuscript Open Access Reviewer Guidelines Librarians Institutional Subscriptions Usage Stats Support Contact Us Subscribe Resources Media Kit About International Access Terms of Use Privacy Statement FAQ AAP.org shopAAP Follow American Academy of Pediatrics on Instagram Visit American Academy of Pediatrics on Facebook Follow American Academy of Pediatrics on Twitter Follow American Academy of Pediatrics on Youtube RSS © 2021 American Academy of Pediatrics