Association of TH17 cell and IL-17A With Autoimmune Inflammatory Disorders: A Review

T helper17 cells consider as essential pathogenic T cell subset in some pathological situations that associated with T helper1 cells. The pathology of autoimmune diseases are related with these cells and also these cells important in the clearance of extracellular infections. Interleukin17A is the major cytokine that produced from T helper 17 cells. These cells in addition to Treg cells are differentiated from naive T cells and can be controlled by cytokine milieu, such as Treg cells induction need for transforming growth factor β, whereas the same cytokine stimulates the T helper 17 populations to differentiate under effect of interleukin 6 or interleukin1. Furthermore, the T helper 17 can be maintenance by interleukin 23. The massive information about T helper 17 is fundamental for recognition of its etiological participation and for evolution of therapeutic approach that related with combat T helper 17 related diseases. In this review, we effort to highlight on the importance of these cells and their cytokines in expansion of autoimmune diseases in human.