脂质体
光热治疗
材料科学
生物物理学
纳米技术
小泡
化学
膜
生物
生物化学
作者
Hejian Xiong,Xiuying Li,Peiyuan Kang,John Perish,Frederik Neuhaus,Jonathan E. Ploski,Sven Kroener,Maria O. Ogunyankin,Jeong Eun Shin,Joseph A. Zasadzinski,Hui Wang,Paul A. Slesinger,Andréas Zumbuehl,Zhenpeng Qin
标识
DOI:10.1002/anie.201915296
摘要
Remote and minimally-invasive modulation of biological systems with light has transformed modern biology and neuroscience. However, light absorption and scattering significantly prevents penetration to deep brain regions. Herein, we describe the use of gold-coated mechanoresponsive nanovesicles, which consist of liposomes made from the artificial phospholipid Rad-PC-Rad as a tool for the delivery of bioactive molecules into brain tissue. Near-infrared picosecond laser pulses activated the gold-coating on the surface of nanovesicles, creating nanomechanical stress and leading to near-complete vesicle cargo release in sub-seconds. Compared to natural phospholipid liposomes, the photo-release was possible at 40 times lower laser energy. This high photosensitivity enables photorelease of molecules down to a depth of 4 mm in mouse brain. This promising tool provides a versatile platform to optically release functional molecules to modulate brain circuits.
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