介孔二氧化硅
材料科学
纳米复合材料
纳米技术
药物输送
介孔材料
纳米颗粒
制作
粒径
化学工程
化学
有机化学
催化作用
替代医学
病理
工程类
医学
作者
Vishal Pande,Prajakta Vilas Khedkar,Mahendra Giri,Ajinkya Pote,Satish Polshettiwar
标识
DOI:10.1080/10667857.2020.1734729
摘要
The research aims at the fabrication and characterisation of magnetically responsive mesoporous silica nanocomposites (MSNs), which can play therapeutic and diagnostic (theranostic) roles simultaneously. The ultimate goal was to create a smart hybrid stimuli-responsive nano cargo that can be used for diagnostic purposes and the therapeutic action of which can be controlled. Magnetic nanoparticles were synthesised by the green synthesis, and mesoporous silica nanoparticles were obtained using the sol–gel method. The nanoparticles were further functionalised using (3-aminopropyltriethoxysilane). Physicochemical characterisation of the drug-loaded MSNs was performed using sophisticated analytical techniques such as infrared spectroscopy, particle size analysis, transmission electron microscopy, drug uptake studies, fluorescence microscopy and BET analysis. The particle size of SBA-15 was found to be 98 nm. The surface area of SBA-15 was 459.79 m2/gm. The drug-loaded SBA-15 showed a 49.3% drug release within 10 h in phosphate buffer of pH 7.4.
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