纳米技术
药物输送
癌症治疗
靶向给药
纳米材料
毒品携带者
纳米颗粒
纳米医学
材料科学
癌症
药品
药理学
医学
内科学
作者
Haroon Khan,Hamid Reza Mirzaei,Amin Amiri,Esra Küpeli Akkol,Syed Muhammad Ashhad Halimi,Hamed Mirzaei
标识
DOI:10.1016/j.semcancer.2019.12.004
摘要
Cancer is known as one of the most common diseases that are associated with high mobility and mortality in the world. Despite several efforts, current cancer treatment modalities often are highly toxic and lack efficacy and specificity. However, the application of nanotechnology has led to the development of effective nanosized drug delivery systems which are highly selective for tumors and allow a slow release of active anticancer agents. Different Nanoparticles (NPs) such as the silicon-based nano-materials, polymers, liposomes and metal NPs have been designed to deliver anti-cancer drugs to tumor sites. Among different drug delivery systems, carbohydrate-functionalized nanomaterials, specially based on their multi-valent binding capacities and desirable bio-compatibility, have attracted considerable attention as an excellent candidate for controlled release of therapeutic agents. In addition, these carbohydrate functionalized nano-carriers are more compatible with construction of the intracellular delivery platforms like the carbohydrate-modified metal NPs, quantum dots, and magnetic nano-materials. In this review, we discuss recent research in the field of multifunctional glycol-nanoparticles (GNPs) intended for cancer drug delivery applications.
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