化学
活性氧
烟酰胺腺嘌呤二核苷酸磷酸
卵清蛋白
激进的
体内
光动力疗法
超氧化物
生物物理学
氧化酶试验
生物化学
有机化学
酶
免疫学
抗原
生物技术
生物
作者
Shuai Jiang,Ming Xiao,Wen Sun,Daniel Crespy,Volker Mailänder,Xiaojun Peng,Jiangli Fan,Katharina Landfester
标识
DOI:10.1002/anie.202006649
摘要
Abstract The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O 2 .− produced by the PDT is converted to H 2 O 2 by superoxide dismutase, followed by the transformation of H 2 O 2 to the highly toxic . OH via Fenton reactions by Fe 2+ originating from the dissolution of co‐loaded Fe 3 O 4 nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus—even for drug‐resistant cells. Cisplatin generates O 2 .− in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O 2 .− source for production of . OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.
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