姜黄素
医学
溃疡性结肠炎
荟萃分析
随机对照试验
内科学
临床试验
耐火材料(行星科学)
疾病
胃肠病学
药理学
天体生物学
物理
作者
Ricardo de Alvares Goulart,Sandra Maria Barbalho,Claudio José Rubira,Adriano Antunes de Souza Araújo,Vinícius Moreira Lima,Buchaim Rogerio Leoni,Elen Landgraf Guiguer
标识
DOI:10.1080/17474124.2020.1808460
摘要
Despite significant advances in the study of Ulcerative colitis (UC) management, up to a third of patients may be refractory to conventional therapy, and specialists have considered natural compounds such as curcumin.The meta-analyzes found in the literature compare the effects of curcumin used in different administration routes or compare patients in remission with patients with active disease. Due to the biases in these studies, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) that investigated the efficacy of orally administrated curcumin in mild-to-moderate active UC.Curcumin produces relevant anti-inflammatory and antioxidant effects that are crucial in inducing remission in UC patients. Unfortunately, in the treatment of UC, we have not observed studies with standardization of dose and routes of administration. Existing meta-analyses are biased because they compare studies using different administration routes and patients in different stages of the disease. Our meta-analysis is the only one that tried to make a comparison with a few of biases as possible and show that curcumin can help in the induction of remission in UC subjects.
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