克拉斯
胰腺癌
微卫星不稳定性
腺癌
癌症
内科学
医学
免疫组织化学
肿瘤科
DNA错配修复
癌症研究
生物
结直肠癌
基因
遗传学
微卫星
等位基因
作者
Robert C. Grant,Robert E. Denroche,Gun Ho Jang,Klaudia Nowak,Amy Zhang,Ayelet Borgida,Spring Holter,James T. Topham,Julie M. Wilson,Anna Dodd,Raymond Woo-Jun Jang,Rebecca M. Prince,Joanna M. Karasinska,David F. Schaeffer,Yifan Wang,George Zogopoulos,Scott Berry,Diane M. Simeone,Daniel J. Renouf,Faiyaz Notta
出处
期刊:Gut
[BMJ]
日期:2020-09-15
卷期号:70 (10): 1894-1903
被引量:70
标识
DOI:10.1136/gutjnl-2020-320730
摘要
OBJECTIVE: To describe the clinical, pathological and genomic characteristics of pancreatic cancer with DNA mismatch repair deficiency (MMRD) and proficiency (MMRP). DESIGN: We identified patients with MMRD and MMRP pancreatic cancer in a clinical cohort (N=1213, 519 with genetic testing, 53 with immunohistochemistry (IHC)) and a genomic cohort (N=288 with whole-genome sequencing (WGS)). RESULTS: . MMRD tumours were significantly more likely to have a basal-like transcriptional programme and elevated transcriptional markers of immunogenicity. CONCLUSIONS: MMRD pancreatic cancers have distinct clinical, pathological and genomic profiles. Patients with MMRD pancreatic cancer should be considered for basket trials targeting enhanced immunogenicity or the unique genomic drivers in these malignancies.
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