血管生成
伤口愈合
姜黄素
体内
光热治疗
材料科学
医学
药理学
癌症研究
化学
纳米技术
免疫学
生物
生物技术
作者
Yang Xi,Gloria Juan,Min Wang,I‐Ming Chen,Wen Niu,Wei Cheng,Yumeng Xue,Cai Lin,Bo Lei
出处
期刊:ACS Nano
[American Chemical Society]
日期:2020-02-07
卷期号:14 (3): 2904-2916
被引量:245
标识
DOI:10.1021/acsnano.9b07173
摘要
Traditional skin tumor surgery and chronic bacterial-infection-induced wound healing/skin regeneration is still a challenge. The ideal strategy should eliminate the tumor, enhance wound healing/skin formation, and be anti-infection. Herein, we designed a multifunctional elastomeric poly(l-lactic acid)–poly(citrate siloxane)–curcumin@polydopamine hybrid nanofibrous scaffold (denoted as PPCP matrix) for tumor-infection therapy and infection-induced wound healing. The PPCP matrix showed intrinsically multifunctional properties including antioxidative, anti-inflammatory, photothermal, antibacterial, anticancer, and angiogenesis bioactivities. The polydopamine/curcumin presented an excellent near-infrared photothermal/cancer cell toxicity capacity, respectively, which supported PPCP for synergetic skin tumor therapy and antibacterial properties in vitro/in vivo. Additionally, the PPCP nanofibrous matrix significantly promotes the adhesion and proliferation of normal skin cells and accelerates the cutaneous wound healing in normal mice and bacterial-infected mice by enhancing the early angiogenesis. The PPCP nanofibrous matrix with multifunctional bioactivities provides a competitive strategy for skin tumor and bacterial-infection-induced wound healing.
科研通智能强力驱动
Strongly Powered by AbleSci AI