自噬
中医药
细胞凋亡
程序性细胞死亡
癌症研究
癌症
癌细胞
免疫系统
医学
生物
药理学
免疫学
内科学
病理
遗传学
替代医学
作者
Wenhui Xu,Cang-Hai Li,Jiang Ting-liang
出处
期刊:PubMed
日期:2018-10-01
卷期号:43 (20): 4019-4026
被引量:10
标识
DOI:10.19540/j.cnki.cjcmm.20180517.001
摘要
Ferroptosis is a new form of regulated cell death which is different from apoptosis, necrosis and autophagy, and results from iron-dependent lipidperoxide accumulation. Now, it is found that ferroptosis is involved in multiple physiological and pathological processes, such as cancer, arteriosclerosis, neurodegenerative diseases, diabetes, antiviral immune response, acute renal failure, hepatic and heart ischemia/reperfusion injury. On the one hand, it could be found the appropriate drugs to promote ferroptosis to clear cancer cells and virus infected cells, etc. On the other hand, we could inhibit ferroptosis to protect healthy cells. China has a wealth of traditional Chinese medicine resources. Chinese medicine contains a variety of active ingredients that regulate ferroptosis. Here, this paper reported the research of ferroptosis pathway, targets of its inducers and inhibitors that have been discovered, and the regulatory effects of the discovered Chinese herbs and its active ingredients on ferroptosis to help clinical and scientific research.
科研通智能强力驱动
Strongly Powered by AbleSci AI