阿托品
手性(物理)
轴手性
化学
部分
对映选择合成
轴对称性
组合化学
立体化学
催化作用
有机化学
物理
手征对称破缺
夸克
Nambu–Jona Lasinio模型
量子力学
作者
Yong-Bin Wang,Quan‐Hao Wu,Zhipeng Zhou,Shao‐Hua Xiang,Yuan Cui,Peiyuan Yu,Bin Tan
标识
DOI:10.1002/anie.201907470
摘要
Axially chiral 2-arylpyrrole frameworks are efficiently accessed through a direct chirality transfer strategy by rapid cyclization of enantioenriched atropisomeric alkenes, which are generated by organocatalytic asymmetric N-alkylation reactions. This approach accommodates a broad scope of substrates with remarkably high chirality transfer efficiency, affording novel atropisomers with a fully substituted pyrrole moiety and high enantiopurities. Given the enantioenriched atropisomeric alkenes, novel heterocyclic 2-arylazepine atropisomers were realized through a rationally designed ene reaction.
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