化学
三氟甲基化
环丁砜
卤化物
芳基
氟化物
铯
氯化物
亲核细胞
亲核芳香族取代
药物化学
有机化学
氟化钾
亲核取代
无机化学
催化作用
三氟甲基
溶剂
烷基
作者
Bernard R. Langlois,Nicolas Roques
标识
DOI:10.1016/j.jfluchem.2007.08.001
摘要
When associated with an alkaline halide, such as cesium fluoride or cesium chloride, and Cu(I) species, methyl trifluoroacetate (MTFA) constitutes a valuable trifluoromethylating agent for substituting aromatic (or heteroaromatic) iodides and bromides. The reaction can be carried out in DMF at 180 °C or, better, in sulfolane which allows he reaction to proceed at a lower temperature (from 140 °C).
科研通智能强力驱动
Strongly Powered by AbleSci AI