细胞生物学
钙信号传导
串扰
免疫系统
内质网
效应器
分泌物
胞浆
免疫
T细胞
信号转导
生物
免疫学
生物化学
酶
物理
光学
作者
Mohamed Trebak,Jean Pierre Kinét
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2019-01-08
卷期号:19 (3): 154-169
被引量:303
标识
DOI:10.1038/s41577-018-0110-7
摘要
Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca2+ regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Several types of plasma membrane and organellar Ca2+-permeable channels are functional in T cells. They contribute highly localized spatial and temporal Ca2+ microdomains that are required for achieving functional specificity. While the mechanistic details of these Ca2+ microdomains are only beginning to emerge, it is evident that through crosstalk, synergy and feedback mechanisms, they fine-tune T cell signalling to match complex immune responses. In this article, we review the expression and function of various Ca2+-permeable channels in the plasma membrane, endoplasmic reticulum, mitochondria and endolysosomes of T cells and their role in shaping immunity and the pathogenesis of immune-mediated diseases. Regulated calcium signalling, in particular downstream of the T cell receptor, is crucial for many T cell effector functions. This Review provides an overview of the numerous membrane and organellar calcium-permeable channels that are coordinated to fine-tune T cell immunity.
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