Effects of Mn concentration on the ac magnetically induced heating characteristics of superparamagnetic MnxZn1−xFe2O4 nanoparticles for hyperthermia

The effects of Mn2+ cation concentration on the ac magnetically induced heating characteristics and the magnetic properties of superparamagnetic MnxZn1−xFe2O4 nanoparticles (SPNPs) were investigated to explore the biotechnical feasibility as a hyperthermia agent. Among the MnxZn1−xFe2O4 SPNPs, the Mn0.5Zn0.5Fe2O4 SPNP showed the highest ac magnetically induced heating temperature (ΔTac,mag), the highest specific absorption rate (SAR), and the highest biocompatibility. The higher out of phase susceptibility (χm″) value and the higher chemical stability systematically controlled by the replacement of Zn2+ cations by the Mn2+ cations on the A-site (tetrahedral site) are the primary physical reason for the promising biotechnical properties of Mn0.5Zn0.5Fe2O4 SPNP.