Objective To analyze mortality cause of respiratory disease and to explore the measures for its prevention and control. Methods The mortality rate and proportion, the characteristic of distribution in respiratory disease were analyzed in terms of the death data. Results The mortality rate of respiratory disease was 84.27 / 100 000 in An'ren county from 2004 to 2005, which was the third leading cause of death in total registered death. The mortality rate of chronic obstructive pulmonary disease (COPD) and pneumonia were 70.07/100 000 and 10.42/100 000, which became the first and second leading cause of death in respiratory diseases. There were two peaks of death rates in persons aged 14 and 75 years, which were the third leading cause, and in persons aged 75 years or older was the second of the total registered death. No difference of mortality rate was found between males and females. The morality rate of inhabitants in the urban areas was lower than that in the rural areas(P0.05). Conclusion An'ren County remains higher mortality rate of respiratory disease, and chronic obstructive pulmonary disease and pneumonia are the main causes of death. The prevention and control of respiratory disease should be strengthened to reduce the death harm to inhabitants.